Too much calorie intake and a sedentary lifestyle can increase the deposition and storage of cholesterol in the body in the form of 'plaques' within the blood vessels (atherosclerosis). It is very harmful as it narrows the spaces within blood vessels for the blood to flow; therefore, blood supply is inadequate to the tissues leading to common signs of fatigue, breathlessness, and increased heart rate to compensate. A raised bad cholesterol can predispose a person to chronic heart and blood vessel diseases.